A very shiny nose?
This problem explores the biology behind Rudolph's glowing red nose, and introduces the real life phenomena of bacterial quorum sensing.
Problem
Sadly, Rudolph catches a nasty cold, which, by the time he is better, has killed all of the bacterial cells in his nose except for one. Santa is worried: there are only $24$ hours left until they need to set off to deliver Christmas presents. Will Rudolph's nose be glowing again in time?
If you need any data that is not included, try to estimate it: Santa wants an answer now, so that he can make alternative plans if need be.
Read about the Hawaiian Bobtail Squid and its relationship with Aliivibrio fischeri.
Watch "How bacteria talk", a TED talk by Bonnie Bassler, for a description of how quorum sensing works (which also features the Hawaiian Bobtail Squid and Aliivibro fischeri).
Find out more about reindeer noses here.
Getting Started
If we assume the starting time is midnight one day, and they have to set off at midnight the next day, how many bacteria will we have at 00:30? How many at 02:00? How many at 23:30?
Since there is a half-life of 10 minutes (which means that every 10 minutes half of the molecules of $X$ disappear), you can probably ignore most of the $X$ produced until near the end of the 24 hours.
You will need an estimate for the volume of Rudolph's nose. You might like to model it as a sphere. You might find this webpage helpful.
Teachers' Resources
Why use this problem?
This problem is based on real-life biology, and also includes the concept of half-life. Students will need to decide how to use the information that they are given, and will need to do some estimating.
The idea of bounds is very useful here. Students can try to find a number for $X$ which they know is an underestimate. They can also try and find an overestimate for the volume of Rudolph's nose.
You can download a word and pdf version of this problem.
Key Questions
- What do we know? What do we not know, which we need to know?
- How might we estimate what we don't know?
- How many bacteria do we have after 30 minutes? How many after 1 hour? How many at the end of the 24 hours?
- If we have $n$ bacteria, how many molecules of $X$ will have been emitted during a 10 minute period? Can you find an underestimate for the number of molecules of $X$ left at the end of the 10 minutes, assuming that the half life is 10 minutes.
- If we think of the molecules of $X$ emitted near the start of the 24 hours, most of them will have decayed by the end of the day, which means we can ignore any early molecules. At what point should we stop ignoring them?
This website gives the sizes of various sports ball which might be useful.
Possible Extension
Can you find an upper limit for the size of Rudolph's nose?
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