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Many thanks to Andrei Lazanu of Bucharest for the following solution.
I know that the area of the circle of radius $r$ is $\pi r^2$.
1) Here, the side of the red square is $2r$.
2) Here I look at the diagonal of the red square, that is half the side of the blue square:
I look at the right-angled triangle, with the hypotenuses half the diagonal of the red square, and two sides of lengths equal to the radii of the first (interior) circle. It is also an isosceles triangle. The radius of the big circle is the hypotenuses of the described triangle. Its length is $r \sqrt{2}$.
3) Here, I observe that I need to calculate the radius of the biggest circle, by multiplying the previous result by $\sqrt{2}$ obtaining $2r$. The area of the orange square is $16r^2$ , and of the circle $2\pi r^2$.
Now, the area of the orange portion is
$$ 16r^2 - 4\pi r^2 = 4r^2(4-\pi) $$4) Now I look at the general case: there are n circles, the first having the radius $r$. The radius of the $n$-th circle will be
$$ r(\sqrt{2})^{n-1} $$
The area of the corresponding square is:
$$4 r^2 \left(\sqrt{2}\right)^{2(n-1)}=4 r^2 2^{n-1}=2^{n+1}r^2$$
and of the corresponding circle:
$$\pi r^2\left(\sqrt{2}\right)^{2(n-1)}= \pi r^2 2^{n-1} = 2^{n-1} \pi r^2 $$
I calculate the shaded region:
$$2^{n+1}r^2 - 2^{n-1}\pi r^2 = 2^{n-1}r^2 (4-\pi)$$which has as particular cases exactly what I obtained before.
For this part of the problem, I must go back to smaller and smaller radii of circles: I have to divide each time by $ \sqrt{2} $ to obtain the new radius. So, for the $n$-th square in the image, the blue part will be:
The numerator is a geometric progression with common ratio $2$
and $n$ terms.
$$S=r^2(4-\pi)\left(\frac{2^{n}-1}{2^{n-1}}\right) $$
But, in this case $n$ is infinite, so
$$ \frac{1}{2^{n-1}} $$